TNF beta

MGI MGI:104797

MGI SwissProt PhenOntology TIGRaffy AffyNA Affy Unigene RefSeq LocusLink GeneOntology

MGI Top

ID: MGI:104797
Symbol: Lta
Name: lymphotoxin A

ID: TNFB_MOUSE
Accession: P09225
Name: LTA
Species: Mus musculus
Protein: Lymphotoxin-alpha precursor (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1).
Functions: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

PhenOntology Top

ID: MP:0000716
Name: immune system: cellular abnormalities
ID: MP:0000716
Name: immune system: cellular abnormalities
ID: MP:0001790
Name: immune system: response/function abnormalities
ID: MP:0001790
Name: immune system: response/function abnormalities
ID: MP:0002123
Name: hematology: hematopoietic anomalies
ID: MP:0002132
Name: respiratory system: dysmorphology
ID: MP:0002138
Name: liver/hepatic system: dysmorphology
ID: MP:0002150
Name: immune system: no defect detected
ID: MP:0002150
Name: immune system: no defect detected
ID: MP:0002169
Name: no phenotype: no defect detected
ID: MP:0002169
Name: no phenotype: no defect detected
ID: MP:0002169
Name: no phenotype: no defect detected
ID: MP:0002722
Name: immune system: organ abnormalities
ID: MP:0002722
Name: immune system: organ abnormalities
ID: MP:0002722
Name: immune system: organ abnormalities
ID: MP:0002722
Name: immune system: organ abnormalities

TIGRaffy Top

ID: ET63426_s_at
Name: strain NOD tumor necrosis factor alpha (TNFA) gene exon 2 and 3

AffyNA Top

ID: m17015_at
GenBank: m17015

Affy Top

ID: 102630_s_at
ID: 1420353_at
ID: m17015_g_at

Unigene Top

ID: Mm.87787
Title: lymphotoxin A
Gene: Lta
Cytoband: 17 19.06 cM

RefSeq Top

ID: NM_010735

LocusLink Top

ID: 16992
Symbol: Lta
Name: lymphotoxin A

GeneOntology Top

ID: 0005125
Name: cytokine activity
ID: 0005164
Name: tumor necrosis factor receptor binding
ID: 0005615
Name: extracellular space
ID: 0006927
Name: killing transformed cells
ID: 0006954
Name: inflammatory response
ID: 0006955
Name: immune response
ID: 0006959
Name: humoral immune response
ID: 0006968
Name: cellular defense response
ID: 0007515
Name: lymph gland development
ID: 0008151
Name: cell growth and/or maintenance
ID: 0008283
Name: cell proliferation
ID: 0008284
Name: positive regulation of cell proliferation
ID: 0016020
Name: membrane

Expression Profile Top

Gene ID

ET63426_s_at

m17015_at

m17015_g_at

non-pregnant avg

390.64

497.27

723.79

14days avg

349.67

457.38

613.07

14days fold

-1.12

-1.09

-1.18

16days avg

373.82

488.64

616.73

16days fold

-1.04

-1.02

-1.17

16v14 fold

1.07

1.01

17days avg

338.62

447.45

598.75

17days fold

-1.15

-1.11

-1.21

17v16 fold

-1.1

-1.09

-1.03

18days avg

334.79

468.45

623.42

18days fold

-1.17

-1.06

-1.16

18v14 fold

-1.04

1.02

18v16 fold

-1.12

-1.04

1.01

18v17 fold

-1.01

1.05

1.04

6hrs avg

382.1

432.45

571.26

6hrs fold

-1.02

-1.15

-1.27

6v18 fold

1.14

-1.08

-1.09

24hrs avg

318.39

460.89

617.75

24hrs fold

-1.23

-1.08

-1.17

24v18 fold

-1.05

-1.02

-1.01

24v6 fold

-1.2

1.07

1.08

GenBank

Y00467

M17015

GenMAPP ID

P06804

P09225

Gene_Symbol

NULL

Lta

MapLocation

NULL

17 19.06 cM

f-rawp

0.0009

0.4396

0.4453

f-adjp

0.857

gestation >20p

post>20p

gestation<-20p

post<-20p

Sum all

np fold-log

14d fold-log

-0.16

-0.12

-0.24

16d fold-log

-0.06

-0.03

-0.23

17d fold-log

-0.21

-0.15

-0.27

18d fold-log

-0.22

-0.09

-0.22

6hrs fold-log

-0.03

-0.2

-0.34

24hrs fold-log

-0.3

-0.11

-0.23

final cluster

1.13E+15

NULL

main cluster

11257000

NULL

2nd level cluster

NULL

main/medoid order

NULL

Mediod

NULL

total in cluster

NULL

final order

NULL

HOPACH Pattern

Down Throughout

NULL

Abs-main cluster

50000

NULL

Abs final order

3237

NULL

Abs-Pattern

NULL

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